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Maintenance doses of aspirin above 100 mg reduce the effectiveness of BRILINTA and should be avoided; CONTRAINDICATIONS. ASPIRIN DOSE AND BRILINTA EFFECTIVENESS IN PATIENTS WITH ACS. Common interactions include vomiting among females and dyspnoea among males. BRILINTA is contraindicated in patients with a history of intracranial hemorrhage or active pathological bleeding such as peptic ulcer or intracranial hemorrhage Two medications are antiplatelet agents i. This restriction is based on the hypothesis that ASA doses >100 mg somehow decreased ticagrelor's benefit in the Platelet Inhibition and Patient Outcomes (PLATO) U. These founding values are alive and well as NADG celebrates its pioneer spirit by solidifying its partnership with Jacobs Holding AG. BRILINTA 60 MG + ASPIRIN WAS PROVEN TO WORK BETTER THAN ASPIRIN ALONE BRILINTA + aspirin helped protect more patients from having a heart attack or stroke or dying from a cardiovascular event than aspirin alone. 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